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These include personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, history of pancreatitis, severe gastrointestinal disease, and certain other conditions

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Existing conditions, current medications, and potential contraindications are reviewed carefully, particularly when a treatment affects appetite and metabolic pathways

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The STEP 1 trial used 2.4 mg of semaglutide, which is the Wegovy weight-management dose rather than an Ozempic diabetes dose