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Ehling R, Di Pauli F, Lackner P, Rainer C, Kraus V, Hegen H, Lutterotti A, Kuenz B, De Zordo T, Schocke M, Glatzl S, Loscher WN, Deisenhammer F, Reindl M, Berger T (2015) Impact of glatiramer acetate on paraclinical markers of neuroprotection in multiple sclerosis: a prospective observational clinical trial

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Studies show that L-carnitine improves the transport of long-chain fatty acids into the mitochondrial matrix, triggering cardioprotective effects through reduced oxidative stress, inflammation and cell death

While systemic interventionssuch as hypoxia modifiers, radiosensitizers, or immunotherapieshave shown promise in preclinical studies, their clinical translation is often hindered by dose-limiting toxicity, poor tumor specificity, and unpredictable pharmacokinetics [68, 69]