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However, analysis of trial data from five long-acting GLP-1 agonists (exenatide once weekly, taspoglutide, albiglutide, LY2189265 and CJC-1134-PC) revealed that they were more likely than shorter-acting formulations to raise the heart rate (Robinson et al., 2013)
Presented for research literature review only An JH et al
The injectable route does offer better bioavailability since it bypasses first-pass metabolism in the gut and liver, but the total weekly dose from a compounded tirzepatide injection remains well below what studies have used to demonstrate significant metabolic effects
It stimulates insulin release from the pancreas (but only when blood sugar is elevated)
The soluble clarified fraction was recovered by centrifuging at 75,000 g for 20 min at 4 C and applied to a Superdex 200 26/600 column (Cytiva) for SEC, which was run as above
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