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We also observed changes in first-time prescribing volumes that corresponded closely to reported shortages

But there have also been concerns about safety

The divergence in the effect of mutagenesis of residues comprising the TM-binding pocket, even where interactions in the static consensus structures were similar, confirmed that static visualisation of complexes is insufficient to fully understand binding and activation mechanisms, and suggests that the dynamics of peptide-receptor engagement likely play a critical role

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC

Safety data in special populationssuch as pregnant or lactating women, pediatric patients, and those with advanced renal or hepatic impairmentremain limited and require further study