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The following comparison summarizes the key considerations: For patients with intact GI absorption, oral high-dose supplementation (1,000 to 2,000 mcg daily) provides a convenient and cost-effective path to correcting deficiency
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It also looks critically at the challenges that still slow down peptide therapeutics: stability, toxicity, and the uneasy gap between computer models and clinical outcomes
In 2004, Ramaekers et al
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