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When exenatide received FDA approval in 2005, GLP-1R was understood primarily as a pancreatic target, and the incretin system looked like a clean metabolic story
doi: 10.1111/apm.13159 29
(3)A multicenter design to accelerate enrollment and enhance statistical power for detecting subgroup effects and gene-environment interactions
L.Tomaro-DuchesneauC.BrittonR
Disabling CBP/p300-binding to NRF2 broadly attenuated NRF2 transcriptional activity resulting in an altered metabolic (depletion of glutathione) and lipidomic (specific depletion of triglycerides) cellular landscape
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