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In all that time harmful effects have never been shown from overdose

Integrin-Linked Kinase Signalling Research and The ILK pathway has been identified as a critical downstream mediator of TB-500s biological effects and with research characterising how TB-500 engagement of ILK activates PI3K/Akt survival and migration signalling, influences focal adhesion dynamics, and regulates the cell-matrix interaction biology that underlies directed cell migration and survival in tissue repair contexts

That is a meaningful standalone number for a compound that most people only ever discuss as an add-on