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This result might be attributable to the small number of patients and the long duration and severity of T2D, as well as the presence of comorbidities

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Mann DM, Esiri MM (1989) The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Downs syndrome

The Metabolic Profile of Down Syndrome Down syndrome is a complex metabolic and genetic disorder whose root cause, trisomy 21, is an extra copy of chromosome 21 [59]

These mechanisms provide a plausible biological basis for clinical observations linking GLP-1 RAs to improved mood, motivation, and hedonic control independent of weight reduction