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Tirzepatide, a dual GLP-1/GIP receptor agonist has been approved for glycaemic control in type 2 diabetes as well as for obesity management leading in up to 22.5% WL in phase 3 obesity trials

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A 2025 systematic review and meta-analysis of tirzepatide (Masson and colleagues, Reviews in Endocrine and Metabolic Disorders ) found that across seven randomized trials, tirzepatide reduced hsCRP by about 33% and IL-6 by about 18% compared to placebo and the effect held even at the lowest 5 mg dose

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The results showed that JMF4073 inhibits both TMPK and CMPK at a similar IC 50 , 0.17 M, whereas YMU1 is less potent to CMPK (Fig