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Free Radical Research , 55 (4), 405415

Subcutaneous injection provides near 100% bioavailability and systemic distribution, whereas topical application is limited by skin barrier penetration

For persistent, unexplained, or worsening skin conditions, a dermatology referral may be appropriate

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Thus, at the level of a key component of T cell immunity as is antigen presentation, the age-related changes in antigen presenting cells like macrophages and dendritic cells could play a relevant role in the altered initiation and outcome of T cell immune responses(41)