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IGF-1 is a small peptide that circulates in plasma with the majority (98%) bound to the IGF-binding proteins (IGFBP)
Chuljerm H, Maneekesorn S, Somsak V, Ma Y, Srichairatanakool S, Koonyosying P
The IRR is distinct from the EPOR homodimer responsible for erythropoiesis
These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks
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