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Glutathione and Parkinson's disease: is this the elephant in the room

AT1R expression in mesangial cells and podocytes, induced by high glucose levels, promotes intracellular expression of profibrotic and pro-inflammatory mediators, such as transforming-growth factor beta (TGF- ), vascular endothelial growth factor (VGEF), and interleukin-6 (IL-6) leading to hyperplasia and hypertrophy, mainly of the proximal tubule, together with extracellular matrix production (34)

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Indeed, the gdh3 / gdh3 mutant showed reduced assimilation of proline as a carbon and nitrogen source, and with increased ATP concentrations, this may be the reason that the gdh3 / gdh3 mutant stayed in the yeast form

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