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Get my score A Structured Approach to Fading a Benign Lip Spot The labial epithelium renews approximately every 28 days
Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
PMC4217450 KPV anti-inflammatory mechanism NF-B-related signaling, cytokine suppression, and immune-cell effects in cellular and animal models: Luger TA, Brzoska T
