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For example, explaining how GLP-1 medications reduce cardiovascular risk can motivate long-term use

In addition, it suppresses your appetite, so you are less likely to gain back the weight you lost

Acting on widely expressed GLP-1 receptors, these drugs influence multiple signaling pathways involved in metabolism, cardiovascular health, neuroprotection, and anti-inflammatory responses

Semaglutide and dulaglutide were classified as early failure types, exenatide as a random failure type, and liraglutide as a wear-out failure type (Additional file 1: Table S5 for raw data)

Drugs like semaglutide and tirzepatide are reshaping the management of obesity and cardiometabolic disease, with millions of patients now using them for sustained weight loss and risk reduction