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Tirzepatide is an FDA-approved prescription medication marketed as Mounjaro for type 2 diabetes mellitus and Zepbound for chronic weight management in adults with BMI 30 kg/m, or 27 kg/m with at least one weight-related comorbidity
The primary limitation is the gap between preclinical and human data
The FDA added it to injectable semaglutide in January 2025, and it climbs the dose axis like everything else. Burning or tingling skin tracks the dose, not the weight lost, and an active-comparator study put the risk about twice that of another weight-loss drug. The mechanism remains unsettled
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