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What matters is matching the right tool to the right individual, and adjusting the approach as your body responds over time
Tirzepatide patients had a mean weight change of -15.3% at 12 months vs -8.3% in semaglutide patients
In the STEP clinical trials, patients weighing over 100 kg (220 lbs) tended to need the full 2.4 mg maintenance dose for optimal results, while those under 80 kg (176 lbs) sometimes achieved their goals at 1.0 or 1.7 mg
GLP-1 agonists are contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
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