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It is the first injectable weight loss drug to simultaneously activate two separate hormonal pathways, which is why it is called a dual incretin medication
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Retatrutide activates three receptors (GLP-1, GIP, and glucagon) compared to semaglutide's single GLP-1 target and tirzepatide's dual GLP-1/GIP mechanism
Kahn agrees that peptides will likely have a place in medical care
Duration of Benefit The health benefits of GLP-1R agonists are most pronounced within the first year of treatment, with significant improvements in glycated hemoglobin (HbA1c), body mass index (BMI), and cardiovascular outcomes
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