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GLP-1RAs improve hyperglycemia by enhancing insulin secretion through increases in -cell cytoplasmic cyclic adenosine monophosphate [53], which activates protein kinase A (PKA) and, thus, increases in intracellular calcium and triggers insulin exocytosis in a glucose-dependent manner [54]
This extra-high insulin level could trigger a sharp crash in blood sugar levels, leading to symptoms such as fatigue, irritability, difficulty concentrating, dizziness, anxiety, nausea, and shakiness
Women : Women might report joint pain more frequently due to hormonal factors or differing pain perception
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Many studies have shown that GLP-1RAs can treat certain CVDs, such as atherosclerosis and hypertension, and the suggested mechanism involves more than blood glucose control (111, 112)
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