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Consequently, effective tailored therapies can be developed to promote healthy aging and increase healthspan

However, -endorphin-neutralizing antibodies did not affect morroniside-induced IL-10 expression, indicating that IL-10 acts upstream of -endorphin in this signaling cascade [74]

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Across all four key STEP trials, diarrhea led to treatment discontinuation in approximately 1.0% to 1.7% of patients, a figure that underscores the generally self-limiting nature of this side effect

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