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Current animal model systems do not fully recapitulate the pathophysiological conditions in human IC/BPS, and targeting specific molecular pathway disruption in animal models might serve as a better option than existing models
New Scientist
for example, elevated Asp may be accompanied by enhanced IL-1 production and promote an M1-like polarization tendency, and the underlying mechanism may be related to enhanced HIF-1 stability and activation of inflammasome-related pathways (70)
Bioinformatics 30 , 923930 (2014)
1990;258(3 Pt 2):F711-6
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