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In the STEP 3 randomised trial, once weekly semaglutide 2.4 mg used in obese adults without diabetes was associated with 4.9% incidence of gallbladder related disorders (mainly cholelithiasis) compared with 1.5% in the placebo group (1)

doi: 10.1056/NEJMoa1800389 115 LuoQHuYChenXLuoYChenJWangH

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The presence of fever, chills, flank pain, or costovertebral angle tenderness suggests upper urinary tract involvement (pyelonephritis) and requires urgent medical evaluation

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