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Peptides are largely broken down by digestive enzymes in the gut, meaning oral supplements may have little or no physiological effect
Jumping straight to high tirzepatide doses or high retatrutide doses without proper escalation dramatically increases both the severity and duration of GI side effects
The trials differed in duration, populations, doses and statistical methods
Ozempic has undergone extensive clinical trials and has been shown to be safe for long-term use in individuals looking to manage their weight
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