Major Surgery: You should typically stop both supplements and GLP-1 medications before undergoing surgery, as they can affect anesthesia and blood sugar stability
Safety considerations Pregnancy and breastfeeding: Not recommended
Notably, the abundance of butyric acid-producing bacteria is suppressed in NAFLD patients ( Coprococcus , Roseburia , Bifidobacterium , and Butyrivibrio ) in an HFD-induced rat model ( Bifidobacteria, Lactobacillus , Coprococcus , and Allobaculum while decreasing the abundance of Parabacteroides and Dorea
Similarly, Eric Polley, PhD, a UChicago data science and public health expert, recently led a study published in Nature Cardiovascular Research that used statistical modeling to emulate a clinical trial comparing the effects of four different classes of diabetes medication in patients with moderate cardiovascular risk
After shortages of brand-name drugs were resolved, the FDA cracked down on compounded semaglutide and tirzepatide in early 2025, ordering pharmacies to stop making them by spring