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As such, there is a good rationale for leptin analogues in the treatment of obesity
Of note, starting from day 6 onwards, the food-restricted (weight-matched) GLP-1GIP-treated mice required a smaller amount of daily food intake relative to the GLP-1GIPLani-treated mice to match their body weight (Extended Data Fig
Some patients need 6 months on the new drug at maintenance dose before the full weight loss trajectory becomes clear
These come in various forms, including tablets, capsules, and sublingual tablets, which allow better absorption
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![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
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