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[221] The accumulation of excess copper, whether due to a foreign body or Wilson's disease, can lead to deposition in different eye regions, resulting in tissue softening in the sclera, the development of a Kayser-Fleischer ring in the cornea, a greenish hue in the iris, sunflower cataracts in the lens, granular deposits in the vitreous, cellular alterations, and copper buildup in the retina

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Obesity and T2D disrupt the balance between bone formation and resorption, leading to increased bone fragility and fracture risk