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Likewise, disulfidoptosis occurs due to SLC7A11 overexpression leading to excessive cystine uptake and depletion of NADPH, resulting in aberrant actin disulfide bonding, cytoskeletal disruption, and cell death, especially during glucose deprivation (145)

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In the TRIUMPH-1 trial, the 4 mg dose had a lower discontinuation rate due to adverse events than even placebo, suggesting that lower doses are well-tolerated

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