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GHK-Cu modulates gene expression across tissue remodeling pathways, including upregulation of collagen types I and III, decorin, and tissue inhibitors of metalloproteinases, while delivering copper to copper-dependent enzymes like lysyl oxidase and superoxide dismutase

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Compared to livers from control mice, those from HFD-fed mice showed a significantly increased percentage of methylation at the CpG islands of CYP2R1 (Fig

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