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However, as demand for these GLP-1 medications skyrocketed, compounded semaglutide emerged as an alternative during drug shortages

However, it is worth noting these improvements may reflect the physiologic consequences of rapid weight loss rather than reversal of underlying disease mechanisms, and whether such changes would persist without definitive obesity treatment is unknown

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They operate via well-studied mechanisms that impact fat storage, appetite, and energy expenditure

They have different approved indications, dosing schedules, and maximum doses, and substituting one for the other can compromise safety and efficacy