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10.1001/jama.2011.1437 JAMA 83 KnowlesR
Endocannabinoid System and Menopause The endocannabinoid system (ECS) is a complex cell-signaling system vital in maintaining the bodys overall balance or homeostasis
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Some preliminary clinical trials have also been conducted
However, in a sensitivity analysis of the REWIND study with dulaglutide, the relative risk reduction for a 40% or 50% decrease in eGFR was 30% and 44%, both significant, in the dulaglutide group compared to placebo, respectively.92 This lower risk of developing macroalbuminuria was also confirmed in an exploratory analysis of the ELIXA (lixisenatide) study.93 In the EXSCEL study (exenatide LAR), renal episodes were analyzed as additional microvascular episodes, and no differences were observed in the risk of episodes related to decreased eGFR, but differences were observed in the composite episode, which included decreased eGFR and macroalbuminuria, although only after adjustment94 (Table 2)
