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Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients

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Their inherent properties, including low systemic toxicity, site-specific delivery, and the capacity to penetrate biofilm matrices, enable improved local drug concentration and reduce recurrence rates [205]

According to the International Diabetes Federation, 537 million adults were living with diabetes in 2025 and by 2045, the number is projected to increase to 783 million, and the World Health Organization estimates that global obesity prevalence has almost tripled since 1975, and that more than 1.1 billion adults are now considered obese globally

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