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The restoration of the plasma homocysteine level with folate and vitamin B12 combined treatment has been reported to attenuate Alzheimers pathology (i.e., A accumulation, tau hyperphosphorylation) and memory impairment ( 5 Conclusion and future perspectives Besides being compatible osmolytes that stabilize cellular proteins, allowing them to survive in adverse environmental conditions, TMAO and betaine play diverse roles in human health and disease

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Crajoinas RO, Oricchio FT, Pessoa TD, Pacheco BPM, Lessa LMA, Malnic G, et al

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