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As a 31-amino acid analogue of native GLP-1 with a C18 fatty diacid chain attached at position Lys via a gamma-glutamic acid/mini-PEG linker, semaglutide achieves a plasma half-life of approximately 7 days in humans the longest of any GLP-1R agonist through albumin binding and resistance to DPP-IV degradation
Gastrointestinal side effects , such as nausea, vomiting, and reduced appetite, are common with Ozempic and may lead to dehydration or electrolyte imbalances
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