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If the person appears nervous or tense, advise them to put their weight on the leg or arm that you aren't injecting to help relax the muscles

Obese patients (BMI 30-35) often need 400-500mcg achieving similar IGF-1 increases as normal-weight patients at lower doses

Typical Post-Injection Timeline First 24-48 hours: Mild to moderate pain at the injection site Localized warmth and redness Slight swelling around the knee Temporary stiffness or reduced range of motion Days 2-3: Gradual reduction in swelling Decreased pain and tenderness Return to normal mobility Possible spongy sensation when walking [4] The American Academy of Orthopaedic Surgeons notes that patients should avoid excessive activity, such as jogging or heavy lifting for the first 48 hours after injection [2]

Poor aseptic technique on each puncture

Research indicates that some weight regain can occur after discontinuation if lifestyle habits are not maintained