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[3] An increase in cAMP levels might potentially activate protein kinase A (PKA), which in turn might phosphorylate several proteins, such as the voltage-dependent calcium channels in the cell membrane

doi: 10.3390/ijms23147781

The authors use this rationale cautiously to reconcile the mismatch between improved cognition and reduced brain volume, stating A clearance and subsequent shifts in cerebrospinal fluid may therefore have also partially explained their findings