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After numerous manipulations on candidate molecules, one was arrived at that acted as a non-peptide GLP-1 agonist and was given the name orforglipron. Now came the next challenge

What Are GLP-1 Peptide Therapies

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doi:10.1038/nature08636

5.4 Psychiatric Adverse Reactions Exacerbation of Pre-existing Psychosis CNS stimulants may exacerbate symptoms of behavior disturbance and thought disorder in patients with a pre-existing psychotic disorder