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2023 Jun 5.
Specifically, high attained dose was associated with lower: all-cause mortality (RR = 0.42, P 25% group, with a mean patient-level change of 0.2% versus 0.8% relative to the pre-treatment baseline measurement ( P 25% weight loss group (126 mmHg versus 13 mmHg, P 25% weight loss group (75.4 mmHg versus 78.0 mmHg) and progressively larger patient-level declines relative to baseline across the different weight loss strata ( P = 0.002
Start with shorter sessions and lighter loads, and progress gradually
What the SURMOUNT trials established Tirzepatide's weight-management evidence comes chiefly from the SURMOUNT program in The New England Journal of Medicine (2022), with SURMOUNT-OSA addressing obstructive sleep apnea in 2024
For best results, start with 1/4 dose and work up to the full dose over the course of 4 to 10 days
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