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The P9 protein pathway The most compelling mechanism connecting gut bacteria to GLP-1 production is the P9 protein secreted by Akkermansia muciniphila
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It is unclear why the SOD activity was lower in positive captive khulan than in negative ones because the amount of damage was similar between them
Biochem Biophys Res Commun 231:488493 Aureli T, Puccetti C, Di Cocco ME, Arduini A, Ricciolini R, Scalibastri M, Manetti C, Conti F (1999) Entry of [(1,2-13C2)acetyl]-l-carnitine in liver tricarboxylic acid cycle and lipogenesis: a study by 13 C NMR spectroscopy in conscious, freely moving rats
This amplifies gut-to-brain signaling and increases the brains sensitivity to gastrointestinal sensations ( The bloodbrain barrier around the area postrema, is more porous thus allowing it to act as a chemosensory trigger zone for nausea and vomiting ( Unfortunately, beyond the specific GLP-1 pathways, multi-agonist therapies do not bypass the gastrointestinal adverse events despite broader receptor targeting
