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For this reason, they are referred to as prandial GLP-1 receptor agonists

While semaglutide effectively reduces appetite in most individuals, persistent hunger can occur due to insufficient dosing duration, hormonal adaptation, dietary factors, or individual variation in medication response

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This article highlights the evolving understanding of the incretin system over the years, leading to the development of multi-agonists, which hold the potential for marked metabolic benefits, mimicking that seen with bariatric surgery

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