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(37552484) [3] Sustained-release formulations: Guidelines state that charcoal may be useful even after 4 hours if evidence of ongoing absorption is present, e.g., an increasing acetaminophen concentration. (37552484) For an ingestion that was slightly beyond four hours ago, it might be reasonable to empirically give activated charcoal (especially if there is a delayed turnaround time on serial acetaminophen levels)

Klatt P, Pineda Molina E, Perez-Sala D, Lamas S

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[29] Addition of crystalline ascorbic acid dissipates this electrostatic charge and allows packaging of pills with up to 750 mg of the drug