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doi: 10.1210/endo.139.5.5998 151 ZhuTLiCZhangXYeCTangSZhangWet al

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Under oxidative stress, Keap1 is modified and releases Nrf2 to enter the nucleus and promote gene transcription

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When this barrier is compromised by oxidative stress, the skin loses its ability to retain moisture effectively, leading to dryness, flakiness, and premature aging

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