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Metabolic adaptation: You require fewer calories at lower weight
Gradual dose escalation (rather than rapid titration) minimizes metabolic shock and allows the body to adapt
Unblinding Unblinding of the participants will be permissible under the following circumstances: treatment of a participant in a medical emergency that requires knowledge of treatment allocation, treatment of a participant for an adverse event (AE), in the event of a suspected unexpected serious adverse reaction (SAR), and SAR is defined as any untoward medical occurrence that results in death, is life-threatening, requires hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity or is a congenital anomaly or birth defect
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J., Fievez, L., Michels, M., et al
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