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Bloodbrain barrier and BCB are guarding systems of the brain formed mainly by endothelial cells, which separate the central nervous system (CNS) from the general circulatory system of the body, protecting the brain from toxic metabolites and pathogens (Zenaro et al., 2017)

For example, gut microbiota-derived indole-3-acetic acid (3-IAA), a tryptophan metabolite, accumulates in the TME and is oxidized by neutrophil myeloperoxidase (MPO), generating a burst of ROS

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A reliable way of boosting glutathione is to administer its precursor N-acetylcysteine

6 When Glutathione levels drop, the liver struggles to keep up with detox demands, leaving you feeling sluggish or inflamed