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Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses

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This effect is usually mild and temporary, and much less pronounced compared to older peptides like GHRP-2 or GHRP-6, which are known to significantly increase hunger

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