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Disadvantages include the potential for unpleasant gastrointestinal side effects and other health risks

These findings indicate that persistent adipose tissue remodeling occurs irrespective of the magnitude of weight loss, reinforcing the concept of tissue-specific regulation of inflammation and fibrosis

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Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method or add a barrier method of contraception for 4 weeks after initiation and for 4 weeks after each dose escalation with it