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doi: 10.1093/qjmed/hct051 Note: Originally published in February 2015, this article has been revised and updated for accuracy and thoroughness.

Water retention: Temporary mild edema has been reported in IGF-1 interventions due to cell hydration effects

By delivering NAD+ directly into the body, these injections aim to increase NAD+ levels beyond what might be achieved with oral supplements or diet

Always consult with a healthcare provider to determine the right plan for your needs, and to ensure proper monitoring if youre using B12 long-term

This often means that B12 deficiencies go untreated, even in folks with long standing depression and anxiety, often for years