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PMCID: PMC6567160
In contrast, ovarian cancer subtypes lacking CXCL10+ TAMs, such as clear cell carcinoma (CCC), exhibit poorer immune infiltration and worse prognoses
No one called it a weight-loss drug
Kynurenine, a metabolite of tryptophan, upregulates T-cell PD-1 levels by inducing and activating the aryl hydrocarbon receptor (AhR), while AhR upregulates transporters to promote T cells to uptake kynurenine, forming a positive feedback loop and inhibiting anti-tumor immune responses (Liu et al., 2018)
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