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Indeed, recently there have been several studies reporting an impact of acquired 5FU resistance on mitochondrial biology

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Erianin inhibits the oncogenic properties of hepatocellular carcinoma via inducing DNA damage and aberrant mitosis

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It helps regulate metabolism, supports protein synthesis (which is how you build muscle), encourages the breakdown of fat for energy, supports bone growth and density, and helps maintain healthy organ function

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Biochemistry 45 , 360372 (2006)

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