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Costunolide, a sesquiterpene lactone, demonstrated gut-brain regulatory effects in a chronic stress-induced IBS model by increasing levels of serotonin (5-HT), brain-derived neurotrophic factor, GluN2A, p-ERK1/2, and p-CREB in the hippocampus

COPD: Histamine levels and mast cell activation cause bronchial constriction in COPD.[ref][ref] Tinnitus and Menieres: A genetic variant in the H4 receptor increases the risk of Menieres and ringing in the ears

The injections are well-tolerated, with most patients describing them as less uncomfortable than standard insulin injections

Supporting these pathways offers a way to address aging at a deeper biological level