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Data from amplicon sequencing were processed and analyzed by CRISPResso2 ( Statistics and reproducibility GraphPad Prism 10 was used for both statistical analysis (ANOVA) and generation of bar plots

A Bayesian hierarchical model was fitted using the brms framework, specifying percent weight change as a Gaussian outcome with (i) drug-specific smooth dose effects (splines by drug), (ii) treatment duration included as a covariate to account for variability in follow-up time across trials, and (iii) a study-level random intercept to account for between-trial heterogeneity

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Peptides and physical therapy may be particularly complementary

Additional contraceptive methods may be needed during these periods