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The British Menopause Society has highlighted this concern, noting that while there is currently no robust data showing that GLP-1 receptor agonists definitively affect oral progestogen dosing requirements, bleeding patterns, or endometrial risk, the theoretical concern is valid and warrants monitoring

Stuessi C, Hofer P, et al

Elevated levels of pro-inflammatory cytokines, such as Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-), generate massive amounts of reactive oxygen species (ROS)

Because they act over a few hours patients have their hunger greatly reduces the period in which someone feels hungry, leading to a reduction in eating and therefore weight loss

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